Anatomy

From X6AWiki

Anatomy of a Virus    Marc Allaire and Paul Freimuth

May 17, 2004

 

Molecular

structures of viruses near atomic resolution have made a dramatic impact in virology and understanding the role of the virion and its components in viral replication. These studies also revealed the associated-difficulties in obtaining the structure of large macromolecular assemblies. Structural studies of viruses were among the first applications of synchrotron radiation to macromolecular x-ray crystallography and the combination of crystal structure data with electron microscopy. At this workshop we will learned about the latest results on the structure/function relationships of virion and virion components in respect to the life cycle of multiple families of viruses. The main goal of the workshop is to understand the pitfalls of these structural studies. It is intended to be a forum of discussion to highlight the important requirements for the study of viral structure

and the future needs in Structural Virology.

 

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8:30

Introduction / Historical Perspective

9:00

Denis Leclerc (Laval University)
Assembly of Hepatitis C Virus Core Protein

9:30

Michael Chapman (Florida State University)
Adeno-Associated Virus - Structural Studies of a Gene Therapy Vector

10:15

Break

10:45

Huilin Li (Brookhaven National Laboratory)
Genomic RNA Packaging in the Vesicular Stomatitis Virus

11:15

Stacy Benson (The Wistar Institute)
Structural Studies of the Lipid-Containing Bacteriophage PRD1

11:45

John Johnson (The Scripps Research Institute)

Structure-Based Studies of Auto-Catalytic Chemistry in Virus Particles:

Mechanisms and Purpose

12:30

Lunch

13:30

Philip Dormitzer (Harvard Medical School)
Structural Rearrangements during Rotavirus Cell Entry

14:15

Wayne Hendrickson (Columbia University)
Structural Biology of HIV Attachment and Entry into Cells

15:00

Break

15:30

David Stuart (Oxford University)
Motors and Membranes: Where crystallography meets electron microscopy

16:15

Michael Rossmann (Purdue University)
Membranes and Motors: Where electron microscopy meets crystallography

17:00

Discussion: Future of Structural Virology

17:45

Conclusion